The average bus between Mission Viejo and San Ysidro takes 3h 20m and the fastest bus takes 2h 50m. The bus service runs several times per day from Mission Viejo to San Ysidro. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Mission Viejo and San Ysidro. The earliest departure is at 7:00 AM in the morning, and the last departure from Mission Viejo is at 9:30 PM which arrives into San Ysidro at 12:25 AM. All services require a transfer at Santa Ana-Santiago and take an average of 3h 20m. The schedules shown below are for the next available departures.

3h 5m • 1 change

2h 50m • 1 change
Arrives next day

2h 55m • 1 change

3h 5m • 1 change

2h 50m • 1 change
Arrives next day

2h 55m • 1 change

3h 5m • 1 change

2h 50m • 1 change
Arrives next day

2h 55m • 1 change

3h 5m • 1 change

2h 50m • 1 change
Arrives next day

2h 55m • 1 change
Want to know about travelling from Mission Viejo to San Ysidro? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mission Viejo to San Ysidro. However, there are services departing from Mission Viejo station and arriving at San Ysidro station via San Ysidro. The journey, including transfers, takes approximately 3h 20m.
Mission Viejo to San Ysidro bus services, operated by OCTA, depart from Santa Ana station.
Mission Viejo to San Ysidro bus services, operated by OCTA, arrive at San Ysidro station.
The distance between Mission Viejo and San Ysidro is 130.4 km. The road distance is 192 km.
Greyhound Mexico operates a bus from Santa Ana to San Ysidro 3 times a day. Tickets cost $20–35 and the journey takes 2h 20m.