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Mississippi to Des Moines buses

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Trip Overview

The bus between Mississippi and Des Moines takes 21h 50m. The bus runs, on average, 6 times per week from Mississippi to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 50m
Duration
945 mi
Distance
$228
Average price
6 times a week
Frequency

Mississippi to Des Moines bus times

Buses run 6 times a week between Mississippi and Des Moines. The service departs Mississippi at 12:55 PM in the afternoon, which arrives into Des Moines at 11:45:00. All services require a transfer at St Louis Bus Station and take an average of 21h 50m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAGreyhound USAJefferson Lines21h 50m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAGreyhound USAJefferson Lines21h 50m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAGreyhound USAJefferson Lines21h 50m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAGreyhound USAJefferson Lines21h 50m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAGreyhound USAJefferson Lines21h 50m • 2 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Greyhound USAGreyhound USAJefferson Lines21h 50m • 2 changes

Frequently asked questions

Want to know about travelling from Mississippi to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mississippi to Des Moines.ExpandLaunch map view
  • Distance: 945.4 mi
  • Duration: 21h 50m

What companies run services between Mississippi, USA and Des Moines, IA, USA?

You can take a bus from Jackson to Des Moines via St Louis Bus Station, Kansas City Bus Station, and Kansas City in around 19h 30m.

Operators