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Missouri to Florence buses

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Trip Overview

The bus between Missouri and Florence takes 44h 40m. The bus runs, on average, 5 times per week from Missouri to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

44h 40m
Duration
1,096 mi
Distance
$222
Average price
5 times a week
Frequency

Missouri to Florence bus times

Buses run 5 times a week between Missouri and Florence. The service departs Missouri at 3:50 PM in the afternoon, which arrives into Florence at 13:30:00. All services require a transfer at St Louis Bus Station and take an average of 44h 40m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAGreyhound USA44h 40m • 3 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAGreyhound USA44h 40m • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAGreyhound USA44h 40m • 3 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAGreyhound USA44h 40m • 3 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAGreyhound USA44h 40m • 3 changes

Frequently asked questions

Want to know about travelling from Missouri to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Missouri to Florence.ExpandLaunch map view
  • Distance: 1,096.2 mi
  • Duration: 44h 40m

What companies run services between Missouri, USA and Florence, SC, USA?

You can take a bus from Kansas City Bus Station to Florence Bus Station via St Louis Bus Station, St. Louis, Carbondale Intermodal Station, and Atlanta Bus Station in around 23h 35m.

Operators