My Bed Vatican Museum, Rome to Florence Buses

Trip Overview

The average bus between My Bed Vatican Museum, Rome and Florence takes 4h 15m and the fastest bus takes 3h 50m. There is a bus service every few hours from My Bed Vatican Museum, Rome to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 15m
Duration: 287 km
Distance: €32
Average price: Hourly
Frequency

Bus

best

Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus 510 / ...

4h 32m

€16–48

My Bed Vatican Museum, Rome to Florence bus times

Buses run hourly between My Bed Vatican Museum, Rome and Florence. The earliest departure is at 5:48 AM in the morning, and the last departure from My Bed Vatican Museum, Rome is at 10:19 PM which arrives into Florence at 2:10 AM. All services require a transfer at Candia/Mocenigo and take an average of 4h 15m. The schedules shown below are for the next available departures.

Departing Sunday, November 1, 2026

9:06 PM → 1:00 AM
Arrives next day
3h 53m • 1 change
10:19 PM → 2:10 AM
Arrives next day
3h 50m • 1 change

Departing Monday, November 2, 2026

5:48 AM → 10:15 AM
4h 26m • 1 change
7:09 AM → 11:10 AM
4h • 1 change
7:22 AM → 11:45 AM
4h 22m • 1 change
7:54 AM → 12:30 PM
4h 35m • 1 change
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Departing Tuesday, November 3, 2026

5:48 AM → 10:15 AM
4h 26m • 1 change
7:09 AM → 11:10 AM
4h • 1 change
7:22 AM → 11:45 AM
4h 22m • 1 change
7:54 AM → 12:30 PM
4h 35m • 1 change
Show more

Departing Wednesday, November 4, 2026

7:09 AM → 11:10 AM
4h • 1 change
7:22 AM → 11:45 AM
4h 22m • 1 change
7:54 AM → 12:30 PM
4h 35m • 1 change
9:17 AM → 1:25 PM
4h 7m • 1 change
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Departing Thursday, November 5, 2026

5:48 AM → 10:15 AM
4h 26m • 1 change
7:09 AM → 11:10 AM
4h • 1 change
7:22 AM → 11:45 AM
4h 22m • 1 change
7:54 AM → 12:30 PM
4h 35m • 1 change
Show more

Departing Friday, November 6, 2026

5:48 AM → 10:15 AM
4h 26m • 1 change
7:09 AM → 11:10 AM
4h • 1 change
7:22 AM → 11:45 AM
4h 22m • 1 change
7:54 AM → 12:30 PM
4h 35m • 1 change
Show more

Departing Saturday, November 7, 2026

5:51 AM → 10:15 AM
4h 23m • 1 change
7:09 AM → 11:10 AM
4h • 1 change
7:42 AM → 11:45 AM
4h 2m • 1 change
8:07 AM → 12:30 PM
4h 22m • 1 change
Show more

Frequently asked questions

Want to know about travelling from My Bed Vatican Museum, Rome to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.