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Myrtle Beach to Key West (Island) buses

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Trip Overview

The bus between Myrtle Beach and Key West (Island) takes 44h 20m. The bus runs, on average, 2 times per week from Myrtle Beach to Key West (Island). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

44h 20m
Duration
1,085 mi
Distance
$218
Average price
Twice a week
Frequency

Myrtle Beach to Key West (Island) bus times

Buses run twice a week between Myrtle Beach and Key West (Island). The service departs Myrtle Beach at 1:10 PM in the afternoon, which arrives into Key West (Island) at 09:30:00. All services require a transfer at Fayetteville Bus Station and take an average of 44h 20m. The schedules shown below are for the next available departures.

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA44h 20m • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA44h 20m • 2 changes

Frequently asked questions

Want to know about travelling from Myrtle Beach to Key West (Island)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Myrtle Beach to Key West (Island).ExpandLaunch map view
  • Distance: 1,084.9 mi
  • Duration: 44h 20m

What companies run services between Myrtle Beach, SC, USA and Key West (Island), FL, USA?

You can take a bus from Myrtle Beach Bus Station to Key West Airport via Fayetteville Bus Station and Miami Airport Station in around 25h 5m.

Operators