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Myrtle Beach to Port Saint Lucie buses

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Trip Overview

The bus between Myrtle Beach and Port Saint Lucie takes 41h 42m. The bus runs, on average, 3 times per week from Myrtle Beach to Port Saint Lucie. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

41h 42m
Duration
913 mi
Distance
$174
Average price
3 times a week
Frequency

Myrtle Beach to Port Saint Lucie bus times

Buses run 3 times a week between Myrtle Beach and Port Saint Lucie. The service departs Myrtle Beach at 1:10 PM in the afternoon, which arrives into Port Saint Lucie at 06:52:00. All services require a transfer at Fayetteville Bus Station and take an average of 41h 42m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAArea Regional Transit St Lucie41h 42m • 3 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAArea Regional Transit St Lucie41h 42m • 3 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAArea Regional Transit St Lucie41h 42m • 3 changes

Frequently asked questions

Want to know about travelling from Myrtle Beach to Port Saint Lucie? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Myrtle Beach to Port Saint Lucie.ExpandLaunch map view
  • Distance: 912.9 mi
  • Duration: 41h 42m

What companies run services between Myrtle Beach, SC, USA and Port Saint Lucie, FL, USA?

You can take a bus from Myrtle Beach Bus Station to SW PSL Blvd & SE Bayshore Blvd via Fayetteville Bus Station, West Palm Beach Bus Station, and SW Gatlin Blvd & SW Brescia St in around 21h 4m.

Operators