Naples to Casa Santa Sofia, Rome Buses

Trip Overview

The average bus between Naples and Casa Santa Sofia, Rome takes 3h 25m and the fastest bus takes 2h 59m. The bus service runs several times per day from Naples to Casa Santa Sofia, Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 25m
Duration: 222 km
Distance: €31
Average price: Twice daily
Frequency

Bus

best

Take the bus from Napoli P.zza Garibaldi to Roma, Autostazione Tiburtinabus 538 / ...

3h 20m

€20–38

Naples to Casa Santa Sofia, Rome bus times

Buses run twice daily between Naples and Casa Santa Sofia, Rome. The earliest departure is at 2:40 AM at night, and the last departure from Naples is at 10:35 PM which arrives into Casa Santa Sofia, Rome at 1:40 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 3h 25m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

2:40 AM → 5:39 AM
2h 59m • 1 change
8:20 PM → 12:14 AM
Arrives next day
3h 54m • 1 change
9:30 PM → 12:36 AM
Arrives next day
3h 6m • 1 change
9:55 PM → 1:19 AM
Arrives next day
3h 24m • 1 change
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Departing Monday, November 9, 2026

8:20 PM → 12:14 AM
Arrives next day
3h 54m • 1 change
9:30 PM → 12:36 AM
Arrives next day
3h 6m • 1 change
9:55 PM → 1:19 AM
Arrives next day
3h 24m • 1 change

Departing Tuesday, November 10, 2026

8:20 PM → 12:14 AM
Arrives next day
3h 54m • 1 change

Departing Wednesday, November 11, 2026

8:20 PM → 12:14 AM
Arrives next day
3h 54m • 1 change
10:35 PM → 1:40 AM
Arrives next day
3h 5m • 1 change

Departing Thursday, November 12, 2026

8:20 PM → 12:14 AM
Arrives next day
3h 54m • 1 change
9:30 PM → 12:36 AM
Arrives next day
3h 6m • 1 change
9:55 PM → 1:19 AM
Arrives next day
3h 24m • 1 change
10:35 PM → 1:40 AM
Arrives next day
3h 5m • 1 change

Departing Friday, November 13, 2026

10:35 PM → 2:09 AM
Arrives next day
3h 34m • 1 change

Frequently asked questions

Want to know about travelling from Naples to Casa Santa Sofia, Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

What companies run services between Naples, Italy and Casa Santa Sofia, Rome, Lazio, Italy?

FlixBus operates a bus from Napoli P.zza Garibaldi to Roma, Autostazione Tiburtina every 30 minutes. Tickets cost €19–29 and the journey takes 2h 40m.

Operators

Naples to Casa Santa Sofia, Rome buses

Trip Overview

Bus