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Nashville to St. Louis (Region) buses

Find Transport to St. Louis (Region)

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Trip Overview

The average bus between Nashville and St. Louis (Region) takes 6h 28m and the fastest bus takes 5h 50m. The bus service runs several times per day from Nashville to St. Louis (Region). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 28m
Duration
317 mi
Distance
$70
Average price
3 times a day
Frequency

Nashville to St. Louis (Region) bus times

Buses run 3 times a day between Nashville and St. Louis (Region). The earliest departure is at 3:30 AM at night, and the last departure from Nashville is at 2:50 PM which arrives into St. Louis (Region) at 9:30 PM. All services run direct with no transfers required, and take on average 6h 28m. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

  •  → 

    bus bus 6h 45m • Direct
  •  → 

    bus bus 6h 40m • Direct

Departing Thursday, November 5, 2026

  •  → 

    bus bus 5h 50m • Direct
  •  → 

    bus bus 6h 45m • Direct
  •  → 

    bus bus 6h 40m • Direct

Departing Friday, November 6, 2026

  •  → 

    bus bus 5h 50m • Direct
  •  → 

    bus bus 6h 45m • Direct
  •  → 

    bus bus 6h 40m • Direct

Departing Saturday, November 7, 2026

  •  → 

    bus bus 5h 50m • Direct
  •  → 

    bus bus 6h 45m • Direct
  •  → 

    bus bus 6h 40m • Direct

Departing Sunday, November 8, 2026

  •  → 

    bus bus 5h 50m • Direct
  •  → 

    bus bus 6h 45m • Direct
  •  → 

    bus bus 6h 40m • Direct

Departing Monday, November 9, 2026

  •  → 

    bus bus 5h 50m • Direct
  •  → 

    bus bus 6h 45m • Direct
  •  → 

    bus bus 6h 40m • Direct

Departing Tuesday, November 10, 2026

  •  → 

    bus bus 6h 45m • Direct
  •  → 

    bus bus 6h 40m • Direct

Frequently asked questions

Want to know about travelling from Nashville to St. Louis (Region)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Nashville to St. Louis (Region).ExpandLaunch map view
  • Distance: 317 mi
  • Duration: 6h 28m

What companies run services between Nashville, TN, USA and St. Louis (Region), MO, USA?

Greyhound USA operates a bus from Nashville Bus Station to St Louis Bus Station twice daily. Tickets cost $55–90 and the journey takes 6h 40m. Flixbus USA also services this route 5 times a week.

Operators