The average bus between Neu-Isenburg and Karlsruhe takes 2h 52m and the fastest bus takes 2h 19m. There is a bus service every few hours from Neu-Isenburg to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Neu-Isenburg and Karlsruhe. The earliest departure is at 3:35 AM at night, and the last departure from Neu-Isenburg is at 11:17 PM which arrives into Karlsruhe at 1:15 AM. All services require a transfer at Frankfurt and take an average of 2h 52m. The schedules shown below are for the next available departures.

2h 39m • 1 change

1h 1m • 1 change

54 min • 1 change

2h 39m • 1 change

2h 25m • 1 change

3h 3m • 1 change

1h 39m • 1 change

2h 19m • 1 change

2h 25m • 1 change

3h 3m • 1 change

1h 39m • 1 change

2h 19m • 1 change

2h 25m • 1 change

3h 3m • 1 change

44 min • 1 change

1h 39m • 1 change

2h 25m • 1 change

3h 3m • 1 change

44 min • 1 change

1h 39m • 1 change
Want to know about travelling from Neu-Isenburg to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Neu-Isenburg to Karlsruhe. However, there are services departing from Neu-Isenburg station and arriving at Karlsruhe station via Karlsruhe central train station station. The journey, including transfers, takes approximately 2h 52m.
Neu-Isenburg to Karlsruhe bus services, operated by Kreativ Tours GmbH, depart from Frankfurt Airport station.
Neu-Isenburg to Karlsruhe bus services, operated by Kreativ Tours GmbH, arrive at Karlsruhe central train station.
The distance between Neu-Isenburg and Karlsruhe is 117.4 km. The road distance is 160 km.
FlixBus operates a bus from Frankfurt Airport to Karlsruhe central train station hourly. Tickets cost €12–21 and the journey takes 2h 10m. BlaBlaCar Bus also services this route 5 times a day.