The average bus between New York Penn Station and Des Moines takes 37h 54m and the fastest bus takes 33h. The bus service runs several times per day from New York Penn Station to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between New York Penn Station and Des Moines. The earliest departure is at 10:45 AM in the morning, and the last departure from New York Penn Station is at 9:31 PM which arrives into Des Moines at 2:35 PM. All services require a transfer at New York Midtown and take an average of 37h 54m. The schedules shown below are for the next available departures.
Arrives next day

32h • 1 change
Arrives +2 days

41h 4m • 1 change
Arrives next day

32h • 1 change
Arrives +2 days

41h 4m • 1 change
Arrives next day

32h • 1 change
Arrives +2 days

41h 4m • 1 change
Want to know about travelling from New York Penn Station to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from New York Penn Station to Des Moines. However, there are services departing from New York Penn Station station and arriving at Des Moines station via Chicago Bus Station station. The journey, including transfers, takes approximately 37h 54m.
New York Penn Station to Des Moines bus services, operated by Flixbus USA, depart from New York Midtown station.
New York Penn Station to Des Moines bus services, operated by Flixbus USA, arrive at Des Moines station.
Book your New York Penn Station to Des Moines bus tickets online with Flixbus USA and Greyhound USA.
The distance between New York Penn Station and Des Moines is 1,641 km. The road distance is 1,975 km.
You can take a vehicle from New York Penn Station to Des Moines via New York Midtown and Chicago Bus Station in around 24h 28m.