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Niagara Falls to Chicago buses

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Trip Overview

The average bus between Niagara Falls and Chicago takes 20h 24m and the fastest bus takes 13h 6m. The bus runs, on average, 2 times per week from Niagara Falls to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

20h 24m
Duration
576 mi
Distance
Twice a week
Frequency

Niagara Falls to Chicago bus times

Buses run twice a week between Niagara Falls and Chicago. The earliest departure is at 6:03 AM in the morning, and the last departure from Niagara Falls is at 10:05 PM which arrives into Chicago at 10:12 AM. All services require a transfer at Ellicott Street & MTC Static and take an average of 20h 24m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    NFTAGreyhound USAGreyhound USAAmtrak27h 41m • 3 changes
  •  → 

    Arrives next day

    NFTAGreyhound USAGreyhound USAAmtrak13h 6m • 3 changes

Frequently asked questions

Want to know about travelling from Niagara Falls to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Niagara Falls to Chicago.ExpandLaunch map view
  • Distance: 576 mi
  • Duration: 20h 24m

What companies run services between Niagara Falls, ON, Canada and Chicago, IL, USA?

You can take a bus from Main Street & Walnut Avenue to Chicago Union Station via Ellicott Street & MTC Static, Buffalo, Cleveland Bus Station, and Toledo in around 13h 23m.

Operators