The average bus between Nogales and San Ysidro takes 15h 5m and the fastest bus takes 13h 56m. The bus service runs several times per day from Nogales to San Ysidro. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Nogales and San Ysidro. The earliest departure is at 3:00 AM at night, and the last departure from Nogales is at 2:00 PM which arrives into San Ysidro at 5:06 AM. All services require a transfer at Huntington Park and take an average of 15h 5m. The schedules shown below are for the next available departures.


14h 15m • 2 changes


17h 23m • 2 changes
Arrives next day


13h 56m • 2 changes


14h 15m • 2 changes


17h 23m • 2 changes
Arrives next day


13h 56m • 2 changes


14h 15m • 2 changes


17h 23m • 2 changes
Arrives next day


13h 56m • 2 changes


14h 15m • 2 changes


17h 23m • 2 changes
Arrives next day


14h 11m • 2 changes
Want to know about travelling from Nogales to San Ysidro? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Nogales to San Ysidro. However, there are services departing from Nogales station and arriving at San Ysidro station via Huntington Park. The journey, including transfers, takes approximately 15h 5m.
Nogales to San Ysidro bus services, operated by Tufesa Mexico, depart from Nogales station.
Nogales to San Ysidro bus services, operated by Tufesa Mexico, arrive at San Ysidro, CA station.
The distance between Nogales and San Ysidro is 591.8 km. The road distance is 1,109 km.
You can take a bus from Nogales to San Ysidro Bl & I-805 via Huntington Park, San Ysidro, CA, and San Ysidro Transit Center in around 14h 13m.