The average bus between Nogales and Santa Ana takes 14h 50m and the fastest bus takes 11h 10m. The bus service runs several times per day from Nogales to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Nogales and Santa Ana. The earliest departure is at 12:20 AM at night, and the last departure from Nogales is at 1:00 PM which arrives into Santa Ana at 8:29 AM. All services require a transfer at 285 S East End Ave - Pomona and take an average of 14h 50m. The schedules shown below are for the next available departures.



11h 10m • 3 changes



12h • 3 changes
Arrives next day



20h 43m • 3 changes
Arrives next day



24h 30m • 3 changes
Arrives next day



19h 29m • 3 changes



11h 10m • 3 changes



12h • 3 changes
Arrives next day



19h 29m • 3 changes
Want to know about travelling from Nogales to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Nogales to Santa Ana. However, there are services departing from Nogales station and arriving at Santa Ana station via 285 S East End Ave - Pomona. The journey, including transfers, takes approximately 14h 50m.
Nogales to Santa Ana bus services, operated by Tufesa, depart from Nogales, AZ station.
Nogales to Santa Ana bus services, operated by Tufesa, arrive at 285 S East End Ave - Pomona station.
The distance between Nogales and Santa Ana is 702.6 km. The road distance is 894 km.
Tufesa operates a bus from Nogales, AZ to 285 S East End Ave - Pomona every 4 hours. Tickets cost $95–120 and the journey takes 9h 10m.