The average bus between Nové Mesto and Prague takes 4h 48m and the fastest bus takes 4h 35m. The bus service runs several times per day from Nové Mesto to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Nové Mesto and Prague. The earliest departure is at 4:45 AM at night, and the last departure from Nové Mesto is at 11:06 PM which arrives into Prague at 3:55 AM. All services require a transfer, and take on average 4h 48m. The schedules shown below are for the next available departures.

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Want to know about travelling from Nové Mesto to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Nové Mesto to Prague. However, there are services departing from Nové Mesto station and arriving at Prague station via Prague. The journey, including transfers, takes approximately 4h 48m.
Nové Mesto to Prague bus services, operated by Arriva Slovensko, depart from Bratislava, Autobusová stanica Mlynské Nivy station.
Nové Mesto to Prague bus services, operated by Arriva Slovensko, arrive at Prague station.
Book your Nové Mesto to Prague bus tickets online with Arriva Slovensko and FlixBus.
The distance between Nové Mesto and Prague is 291 km. The road distance is 342 km.
FlixBus operates a bus from Bratislava, Autobusová stanica Mlynské Nivy to Prague every 3 hours. Tickets cost Kč 700–1,200 and the journey takes 4h 25m.