The average bus between Novotel Berlin Mitte and Prague takes 5h 12m and the fastest bus takes 4h 58m. There is a bus service every few hours from Novotel Berlin Mitte to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 2 hours between Novotel Berlin Mitte and Prague. The earliest departure is at 6:40 AM in the morning, and the last departure from Novotel Berlin Mitte is at 11:41 PM which arrives into Prague at 5:00 AM. All services require a transfer at Fischerinsel and take an average of 5h 12m. The schedules shown below are for the next available departures.

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5h 23m • 1 changeWant to know about travelling from Novotel Berlin Mitte to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Novotel Berlin Mitte to Prague. However, there are services departing from Berlin Südkreuz train station and arriving at Praha, Hlavní Nádraží station via Praha, Hlavní Nádraží station. The journey, including transfers, takes approximately 5h 12m.
Novotel Berlin Mitte to Prague bus services, operated by FlixBus, depart from Berlin Südkreuz train station.
Novotel Berlin Mitte to Prague bus services, operated by FlixBus, arrive at Praha, Hlavní Nádraží station.
The distance between Novotel Berlin Mitte and Prague is 278.7 km. The road distance is 332 km.
FlixBus operates a bus from Berlin Südkreuz train station to Praha, Hlavní Nádraží hourly. Tickets cost Kč 700–1,100 and the journey takes 4h 25m.