The average bus between O'Hare and Indianapolis takes 5h 38m and the fastest bus takes 5h 2m. The bus service runs several times per day from O'Hare to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between O'Hare and Indianapolis. The earliest departure is at 5:23 AM in the morning, and the last departure from O'Hare is at 5:20 PM which arrives into Indianapolis at 12:05 AM. All services require a transfer at LaSalle and take an average of 5h 38m. The schedules shown below are for the next available departures.


6h 16m • 2 changes


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6h 32m • 2 changes


6h 9m • 2 changes


6h 31m • 2 changes


6h 16m • 2 changes


6h 32m • 2 changes


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6h 26m • 2 changes


6h 28m • 2 changes


6h 2m • 2 changes


6h 26m • 2 changes
Want to know about travelling from O'Hare to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from O'Hare to Indianapolis. However, there are services departing from O'Hare station and arriving at Indianapolis station via Indianapolis Union Station station. The journey, including transfers, takes approximately 5h 38m.
O'Hare to Indianapolis bus services, operated by Chicago Transit (CTA), depart from Chicago Bus Station.
O'Hare to Indianapolis bus services, operated by Chicago Transit (CTA), arrive at Indianapolis Union Station.
The distance between O'Hare and Indianapolis is 283.4 km. The road distance is 314 km.
Greyhound USA operates a bus from Chicago Bus Station to Indianapolis Union Station 5 times a day. Tickets cost $26–50 and the journey takes 3h 5m.