The average bus between Old Lyme and Hyannis takes 14h 25m and the fastest bus takes 9h. The bus service runs several times per day from Old Lyme to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Old Lyme and Hyannis. The earliest departure is at 12:34 PM in the afternoon, and the last departure from Old Lyme is at 6:34 PM which arrives into Hyannis at 12:35 PM. All services require a transfer at Old Saybrook Train Station Bus Shelter and take an average of 14h 25m. The schedules shown below are for the next available departures.
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17h • 3 changes
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18h • 3 changes



9h • 3 changes
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17h • 3 changes
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18h • 3 changes



9h • 3 changes
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17h • 3 changes
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18h • 3 changes
Want to know about travelling from Old Lyme to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Old Lyme to Hyannis. However, there are services departing from Old Lyme station and arriving at Hyannis station via Asylum St @ Union Pl. The journey, including transfers, takes approximately 14h 25m.
Old Lyme to Hyannis bus services, operated by River Valley Transit, depart from Old Saybrook Trans Cntr station.
Old Lyme to Hyannis bus services, operated by River Valley Transit, arrive at Hyannis Transportation Center station.
The distance between Old Lyme and Hyannis is 174.6 km. The road distance is 352 km.
You can take a bus from Lyme St & Library Ln to Hyannis Transportation Center via Old Saybrook Train Station Bus Shelter, Old Saybrook Trans Cntr, Asylum St @ Union Pl, Hartford Union Station, Boston, and Boston South Station in around 7h 40m.