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Old Lyme to Hyannis buses

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Trip Overview

The average bus between Old Lyme and Hyannis takes 15h 23m and the fastest bus takes 7h 40m. The bus service runs several times per day from Old Lyme to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 23m
Duration
220 mi
Distance
$53
Average price
Twice daily
Frequency

Old Lyme to Hyannis bus times

Buses run twice daily between Old Lyme and Hyannis. The earliest departure is at 12:34 PM in the afternoon, and the last departure from Old Lyme is at 6:34 PM which arrives into Hyannis at 1:15 PM. All services require a transfer at Old Saybrook Train Station Bus Shelter and take an average of 15h 23m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    River Valley TransitCT TransitGreyhound USAPlymouth & Brockton7h 40m • 3 changes
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    Arrives next day

    River Valley TransitCT TransitGreyhound USAPlymouth & Brockton9h • 3 changes
  •  → 

    Arrives next day

    River Valley TransitCT TransitFlixbus USAPlymouth & Brockton18h 40m • 3 changes

Departing Friday, November 13, 2026

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    River Valley TransitCT TransitGreyhound USAPlymouth & Brockton8h 40m • 3 changes
  •  → 

    Arrives next day

    River Valley TransitCT TransitGreyhound USAPlymouth & Brockton9h • 3 changes
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    Arrives +3 days

    River Valley TransitCT TransitFlixbus USAPlymouth & Brockton2d 18h • 3 changes

Departing Monday, November 16, 2026

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    River Valley TransitCT TransitGreyhound USAPlymouth & Brockton7h 40m • 3 changes
  •  → 

    Arrives next day

    River Valley TransitCT TransitGreyhound USAPlymouth & Brockton9h • 3 changes
  •  → 

    Arrives next day

    River Valley TransitCT TransitFlixbus USAPlymouth & Brockton18h 40m • 3 changes

Departing Tuesday, November 17, 2026

  •  → 

    River Valley TransitCT TransitGreyhound USAPlymouth & Brockton8h 40m • 3 changes
  •  → 

    Arrives next day

    River Valley TransitCT TransitGreyhound USAPlymouth & Brockton9h • 3 changes
  •  → 

    Arrives next day

    River Valley TransitCT TransitFlixbus USAPlymouth & Brockton18h 40m • 3 changes

Departing Wednesday, November 18, 2026

  •  → 

    River Valley TransitCT TransitGreyhound USAPlymouth & Brockton8h 40m • 3 changes

Frequently asked questions

Want to know about travelling from Old Lyme to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Old Lyme to Hyannis.ExpandLaunch map view
  • Distance: 220.2 mi
  • Duration: 15h 23m

What companies run services between Old Lyme, CT, USA and Hyannis, MA, USA?

You can take a bus from Lyme St & Library Ln to Hyannis Transportation Center via Old Saybrook Train Station Bus Shelter, Old Saybrook Trans Cntr, Asylum St @ Union Pl, Hartford Union Station, Boston, and Boston South Buses in around 7h 37m.

Operators