The average bus between Orange and La Mesa takes 5h 16m and the fastest bus takes 3h 17m. The bus service runs several times per day from Orange to La Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Orange and La Mesa. The earliest departure is at 10:00 AM in the morning, and the last departure from Orange is at 10:05 PM which arrives into La Mesa at 6:51 AM. All services require a transfer at San Diego and take an average of 5h 16m. The schedules shown below are for the next available departures.


3h 17m • 2 changes


3h 45m • 2 changes
Arrives next day


8h 46m • 2 changes


3h 17m • 2 changes


3h 45m • 2 changes
Arrives next day


8h 46m • 2 changes
Want to know about travelling from Orange to La Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Orange to La Mesa. However, there are services departing from Orange station and arriving at La Mesa station via San Diego. The journey, including transfers, takes approximately 5h 16m.
Orange to La Mesa bus services, operated by Greyhound USA, depart from Anaheim station.
Orange to La Mesa bus services, operated by Greyhound USA, arrive at San Diego station.
The distance between Orange and La Mesa is 137.2 km. The road distance is 171 km.
Greyhound Mexico operates a bus from Anaheim to San Diego twice daily. Tickets cost $19–30 and the journey takes 2h 10m.