The average bus between Orange County and San Ysidro takes 3h 34m and the fastest bus takes 2h 37m. The bus service runs several times per day from Orange County to San Ysidro. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Orange County and San Ysidro. The earliest departure is at 10:00 AM in the morning, and the last departure from Orange County is at 10:05 PM which arrives into San Ysidro at 3:56 AM. All services require a transfer, and take on average 3h 34m. The schedules shown below are for the next available departures.

2h 41m • 1 change

2h 51m • 1 change

2h 37m • 1 change
Arrives next day

7h 1m • 1 change

2h 41m • 1 change

2h 51m • 1 change
Arrives next day

5h 51m • 1 change

2h 43m • 1 change

2h 55m • 1 change

2h 38m • 1 change
Arrives next day

5h 51m • 1 change

2h 43m • 1 change

2h 55m • 1 change

2h 38m • 1 change
Arrives next day

5h 51m • 1 change
Want to know about travelling from Orange County to San Ysidro? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Orange County to San Ysidro. However, there are services departing from Orange County station and arriving at San Ysidro station via San Ysidro Bus Terminal. The journey, including transfers, takes approximately 3h 34m.
Orange County to San Ysidro bus services, operated by Flixbus USA, depart from Santa Ana Bus Stop station.
Orange County to San Ysidro bus services, operated by Flixbus USA, arrive at San Ysidro Bus Terminal station.
The distance between Orange County and San Ysidro is 153.9 km. The road distance is 172 km.
Flixbus USA operates a bus from Santa Ana Bus Stop to San Ysidro Bus Terminal 4 times a day. Tickets cost $16–28 and the journey takes 2h 15m. Greyhound USA also services this route 4 times a day.