The average bus between Orio al Serio and Mendrisio takes 6h 40m and the fastest bus takes 3h 52m. The bus service runs several times per day from Orio al Serio to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Orio al Serio and Mendrisio. The earliest departure is at 4:40 AM at night, and the last departure from Orio al Serio is at 7:55 PM which arrives into Mendrisio at 7:34 AM. All services require a transfer at Milan and take an average of 6h 40m. The schedules shown below are for the next available departures.



4h 54m • 3 changes



3h 52m • 3 changes
Arrives next day



11h 27m • 3 changes



4h 54m • 3 changes



3h 52m • 3 changes
Arrives next day



11h 27m • 3 changes



4h 54m • 3 changes



3h 52m • 3 changes
Arrives next day



11h 27m • 3 changes
Want to know about travelling from Orio al Serio to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Orio al Serio to Mendrisio. However, there are services departing from Orio al Serio station and arriving at Mendrisio station via Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 6h 40m.
Orio al Serio to Mendrisio bus services, operated by FlixBus, depart from Bergamo station.
Orio al Serio to Mendrisio bus services, operated by FlixBus, arrive at Como station.
The distance between Orio al Serio and Mendrisio is 58.8 km. The road distance is 116 km.
You can take a bus from Bergamo to Mendrisio, Autosilo via Milan, Como, Como - San Rocchetto, and Chiasso, Stazione in around 4h 14m.