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Orlando Health/Amtrak to Key West buses

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Trip Overview

The average bus between Orlando Health/Amtrak and Key West takes 15h 51m and the fastest bus takes 15h 47m. The bus runs, on average, 6 times per week from Orlando Health/Amtrak to Key West. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 51m
Duration
397 mi
Distance
$83
Average price
6 times a week
Frequency

Orlando Health/Amtrak to Key West bus times

Buses run 6 times a week between Orlando Health/Amtrak and Key West. The earliest departure is at 8:55 PM in the evening, and the last departure from Orlando Health/Amtrak is at 9:15 PM which arrives into Key West at 1:02 PM. All services require a transfer at N Garland Ave & W Amelia St and take an average of 15h 51m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    Lynx Central Florida TransportLynx Central Florida TransportGreyhound USAGreyhound USAKey West Transit15h 47m • 4 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    Lynx Central Florida TransportLynx Central Florida TransportGreyhound USAGreyhound USAKey West Transit15h 47m • 4 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Lynx Central Florida TransportLynx Central Florida TransportFlixbus USAGreyhound USAKey West Transit15h 47m • 4 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Lynx Central Florida TransportLynx Central Florida TransportFlixbus USAGreyhound USAKey West Transit15h 47m • 4 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Lynx Central Florida TransportLynx Central Florida TransportFlixbus USAGreyhound USAKey West Transit15h 53m • 4 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Lynx Central Florida TransportLynx Central Florida TransportFlixbus USAGreyhound USAKey West Transit16h 7m • 4 changes

Frequently asked questions

Want to know about travelling from Orlando Health/Amtrak to Key West? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Orlando Health/Amtrak to Key West.ExpandLaunch map view
  • Distance: 397.2 mi
  • Duration: 15h 51m

What companies run services between Orlando Health/Amtrak, FL, USA and Key West, FL, USA?

You can take a bus from Sligh Blvd & W Copeland Dr to N Roosevelt & 3rd Street via N Garland Ave & W Amelia St, N John Young Pkwy & Business Center Blvd, Orlando Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 13h 25m.

Operators