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Orlando to Florence buses

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Trip Overview

The average bus between Orlando and Florence takes 34h 40m and the fastest bus takes 32h 45m. The bus runs, on average, 6 times per week from Orlando to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

34h 40m
Duration
523 mi
Distance
$107
Average price
6 times a week
Frequency

Orlando to Florence bus times

Buses run 6 times a week between Orlando and Florence. The earliest departure is at 4:45 AM at night, and the last departure from Orlando is at 11:00 PM which arrives into Florence at 1:30 PM. All services require a transfer at Jacksonville and take an average of 34h 40m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA32h 45m • 2 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA32h 45m • 2 changes

Departing Monday, November 9, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA32h 45m • 2 changes
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    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA38h 30m • 2 changes

Departing Tuesday, November 10, 2026

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    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA38h 30m • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA32h 45m • 2 changes

Frequently asked questions

Want to know about travelling from Orlando to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Orlando to Florence.ExpandLaunch map view
  • Distance: 522.5 mi
  • Duration: 34h 40m

What companies run services between Orlando, FL, USA and Florence, SC, USA?

You can take a bus from Orlando Bus Station to Florence Bus Station via Jacksonville and Camden in around 12h 25m.

Operators