The average bus between Orlando and Key Largo takes 7h 40m and the fastest bus takes 7h. The bus service runs several times per day from Orlando to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Orlando and Key Largo. The earliest departure is at 12:45 AM at night, and the last departure from Orlando is at 11:05 PM which arrives into Key Largo at 6:25 AM. All services require a transfer at Sheridan Tri-Rail Station and take an average of 7h 40m. The schedules shown below are for the next available departures.

8h 35m • 1 change

7h • 1 change
Arrives next day

7h 20m • 1 change

8h 35m • 1 change

7h • 1 change
Arrives next day

7h 20m • 1 change
Want to know about travelling from Orlando to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Orlando to Key Largo. However, there are services departing from Orlando station and arriving at Key Largo station via Sheridan Tri-Rail Station station. The journey, including transfers, takes approximately 7h 40m.
Orlando to Key Largo bus services, operated by Flixbus USA, depart from Orlando station.
Orlando to Key Largo bus services, operated by Flixbus USA, arrive at Key Largo Bus Stop station.
Book your Orlando to Key Largo bus tickets online with Flixbus USA and Greyhound USA.
The distance between Orlando and Key Largo is 394.8 km. The road distance is 470 km.
You can take a bus from Orlando to Key Largo Bus Stop via Sheridan Tri-Rail Station, Sheridan Street Station, Miami, Airport Intermodal Station, and Miami Airport Station in around 7h 1m.