Rome2Rio

Orlando to Lake City buses

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Trip Overview

The bus between Orlando and Lake City takes 3h 45m. There is at least one bus per day from Orlando to Lake City. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 45m
Duration
159 mi
Distance
$35
Average price
Once daily
Frequency

Orlando to Lake City bus times

Buses run once daily between Orlando and Lake City. The service departs Orlando at 5:15 AM in the morning, which arrives into Lake City at 09:00:00. All services run direct with no transfers required, and take on average 3h 45m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    bus bus 3h 45m • Direct

Departing Sunday, November 8, 2026

  •  → 

    bus bus 3h 45m • Direct

Departing Monday, November 9, 2026

  •  → 

    bus bus 3h 45m • Direct

Departing Tuesday, November 10, 2026

  •  → 

    bus bus 3h 45m • Direct

Departing Wednesday, November 11, 2026

  •  → 

    bus bus 3h 45m • Direct

Departing Thursday, November 12, 2026

  •  → 

    bus bus 3h 45m • Direct

Frequently asked questions

Want to know about travelling from Orlando to Lake City? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Orlando to Lake City.ExpandLaunch map view
  • Distance: 158.6 mi
  • Duration: 3h 45m

What companies run services between Orlando, FL, USA and Lake City, FL, USA?

Greyhound USA operates a bus from Orlando Bus Station to Lake City Bus Station twice daily. Tickets cost $29–45 and the journey takes 3h 45m.

Operators