The average bus between Orleans and Cambridge takes 5h 15m and the fastest bus takes 2h 20m. The bus service runs several times per day from Orleans to Cambridge. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Orleans and Cambridge. The earliest departure is at 9:45 AM in the morning, and the last departure from Orleans is at 7:15 PM which arrives into Cambridge at 6:00 AM. All services require a transfer, and take on average 5h 15m. The schedules shown below are for the next available departures.

2h 20m • 1 change

2h 40m • 1 change
Arrives next day

10h 45m • 1 change

2h 20m • 1 change

2h 40m • 1 change
Arrives next day

10h 45m • 1 change

2h 20m • 1 change

2h 40m • 1 change
Arrives next day

10h 45m • 1 change
Want to know about travelling from Orleans to Cambridge? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Orleans to Cambridge. However, there are services departing from Orleans station and arriving at Cambridge station via Hyannis Transportation Center. The journey, including transfers, takes approximately 5h 15m.
Orleans to Cambridge bus services, operated by Peter Pan Bus Lines, depart from Orleans station.
Orleans to Cambridge bus services, operated by Peter Pan Bus Lines, arrive at Boston station.
Book your Orleans to Cambridge bus tickets online with Peter Pan Bus Lines.
The distance between Orleans and Cambridge is 112.8 km. The road distance is 148 km.
You can take a bus from Orleans to Boston via Hyannis in around 3h 5m.