The average bus between Otay Mesa and La Jolla takes 3h 43m and the fastest bus takes 2h 17m. The bus service runs several times per day from Otay Mesa to La Jolla. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Otay Mesa and La Jolla. The earliest departure is at 5:29 AM in the morning, and the last departure from Otay Mesa is at 8:43 PM which arrives into La Jolla at 6:33 AM. All services require a transfer at Iris Avenue Transit Center and take an average of 3h 43m. The schedules shown below are for the next available departures.



2h 50m • 3 changes



2h 18m • 3 changes



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2h 17m • 3 changes



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2h 24m • 3 changes



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2h 52m • 3 changes



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2h 26m • 3 changes



2h 36m • 3 changes



2h 37m • 3 changes



3h 11m • 3 changes



2h 39m • 3 changes
Want to know about travelling from Otay Mesa to La Jolla? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Otay Mesa to La Jolla. However, there are services departing from Otay Mesa station and arriving at La Jolla station via San Ysidro Transit Center. The journey, including transfers, takes approximately 3h 43m.
Otay Mesa to La Jolla bus services, operated by San Diego Metro Transit, depart from Iris Avenue Transit Center station.
Otay Mesa to La Jolla bus services, operated by San Diego Metro Transit, arrive at Silverado St & Herschel Av station.
The distance between Otay Mesa and La Jolla is 41.4 km. The road distance is 62 km.
You can take a bus from Otay Mesa Rd & Cactus Rd to Silverado St & Herschel Av via Iris Avenue Transit Center, San Ysidro Bus Terminal, San Diego Greyhound Bus Stop, and Old Town Transit Center in around 3h 3m.