The average bus between Otay Mesa and Los Angeles Union Station takes 7h 22m and the fastest bus takes 4h 19m. The bus service runs several times per day from Otay Mesa to Los Angeles Union Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Otay Mesa and Los Angeles Union Station. The earliest departure is at 11:28 AM in the morning, and the last departure from Otay Mesa is at 8:43 PM which arrives into Los Angeles Union Station at 9:15 AM. All services require a transfer at Iris Avenue Transit Center and take an average of 7h 22m. The schedules shown below are for the next available departures.


5h 12m • 2 changes


4h 37m • 2 changes
Arrives next day


12h 32m • 2 changes


5h 10m • 2 changes


4h 19m • 2 changes
Arrives next day


12h 57m • 2 changes


5h 10m • 2 changes


4h 19m • 2 changes
Arrives next day


12h 57m • 2 changes


5h 10m • 2 changes


4h 19m • 2 changes
Arrives next day


12h 57m • 2 changes


5h 10m • 2 changes


4h 19m • 2 changes
Arrives next day


12h 57m • 2 changes
Want to know about travelling from Otay Mesa to Los Angeles Union Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Otay Mesa to Los Angeles Union Station. However, there are services departing from Otay Mesa station and arriving at Los Angeles Union Station station via Los Angeles Union Station station. The journey, including transfers, takes approximately 7h 22m.
Otay Mesa to Los Angeles Union Station bus services, operated by San Diego Metro Transit, depart from San Ysidro Bus Terminal station.
Otay Mesa to Los Angeles Union Station bus services, operated by San Diego Metro Transit, arrive at Los Angeles Union Station.
The distance between Otay Mesa and Los Angeles Union Station is 202.3 km. The road distance is 238 km.
Greyhound USA operates a bus from San Ysidro Bus Terminal to Los Angeles Union Station 4 times a day. Tickets cost $21–40 and the journey takes 3h 10m. Flixbus USA also services this route twice daily.