Otay Mesa to Mexicali Buses

Otay Mesa to Mexicali buses

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Trip Overview

The average bus between Otay Mesa and Mexicali takes 5h 21m and the fastest bus takes 4h 58m. The bus service runs several times per day from Otay Mesa to Mexicali. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 21m

Duration

189 km

Distance

$583

Average price

Every 4 hours

Frequency

Otay Mesa to Mexicali bus times

Buses run every 4 hours between Otay Mesa and Mexicali. The earliest departure is at 5:01 AM in the morning, and the last departure from Otay Mesa is at 8:43 PM which arrives into Mexicali at 1:45 AM. All services require a transfer at Iris Avenue Transit Center and take an average of 5h 21m. The schedules shown below are for the next available departures.

Departing Saturday, October 24, 2026

4:28 PM → 10:15 PM
5h 47m • 3 changes
5:28 PM → 10:40 PM
5h 12m • 3 changes
6:28 PM → 11:30 PM
5h 2m • 3 changes
8:28 PM → 1:45 AM
Arrives next day
5h 17m • 3 changes

Departing Sunday, October 25, 2026

7:43 AM → 1:40 PM
5h 57m • 3 changes
9:43 AM → 3:40 PM
5h 57m • 3 changes
4:43 PM → 10:15 PM
5h 32m • 3 changes
5:43 PM → 11:30 PM
5h 47m • 3 changes
Show more

Departing Monday, October 26, 2026

5:01 AM → 10:40 AM
5h 39m • 3 changes
8:18 AM → 1:40 PM
5h 22m • 3 changes
10:15 AM → 3:40 PM
5h 25m • 3 changes
5:03 PM → 10:15 PM
5h 12m • 3 changes
Show more

Departing Tuesday, October 27, 2026

5:01 AM → 10:40 AM
5h 39m • 3 changes
8:18 AM → 1:40 PM
5h 22m • 3 changes
10:15 AM → 3:40 PM
5h 25m • 3 changes
5:03 PM → 10:15 PM
5h 12m • 3 changes
Show more

Departing Wednesday, October 28, 2026

5:01 AM → 10:40 AM
5h 39m • 3 changes
8:18 AM → 1:40 PM
5h 22m • 3 changes
10:15 AM → 3:40 PM
5h 25m • 3 changes
5:03 PM → 10:15 PM
5h 12m • 3 changes
Show more

Departing Thursday, October 29, 2026

5:01 AM → 10:40 AM
5h 39m • 3 changes
8:18 AM → 1:40 PM
5h 22m • 3 changes
10:15 AM → 3:40 PM
5h 25m • 3 changes
5:03 PM → 10:15 PM
5h 12m • 3 changes
Show more

Departing Friday, October 30, 2026

5:01 AM → 10:40 AM
5h 39m • 3 changes
8:18 AM → 1:40 PM
5h 22m • 3 changes
10:15 AM → 3:40 PM
5h 25m • 3 changes
5:03 PM → 10:15 PM
5h 12m • 3 changes
Show more

Frequently asked questions

Want to know about travelling from Otay Mesa to Mexicali? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.