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Otay Mesa to Phoenix buses

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Trip Overview

The average bus between Otay Mesa and Phoenix takes 15h 46m and the fastest bus takes 15h 31m. The bus runs, on average, 5 times per week from Otay Mesa to Phoenix. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 46m
Duration
398 mi
Distance
$85
Average price
5 times a week
Frequency

Otay Mesa to Phoenix bus times

Buses run 5 times a week between Otay Mesa and Phoenix. The earliest departure is at 7:43 AM in the morning, and the last departure from Otay Mesa is at 8:28 AM which arrives into Phoenix at 11:59 PM. All services require a transfer at Iris Avenue Transit Center and take an average of 15h 46m. The schedules shown below are for the next available departures.

Departing Saturday, October 24, 2026

  •  → 

    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USA15h 31m • 3 changes

Departing Sunday, October 25, 2026

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    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USA16h 16m • 3 changes

Departing Monday, October 26, 2026

  •  → 

    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USA15h 41m • 3 changes

Departing Tuesday, October 27, 2026

  •  → 

    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USA15h 41m • 3 changes

Departing Thursday, October 29, 2026

  •  → 

    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USA15h 41m • 3 changes

Frequently asked questions

Want to know about travelling from Otay Mesa to Phoenix? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Otay Mesa to Phoenix.ExpandLaunch map view
  • Distance: 397.6 mi
  • Duration: 15h 46m

What companies run services between Otay Mesa, CA, USA and Phoenix, AZ, USA?

Greyhound USA operates a bus from San Ysidro Bus Terminal to Phoenix Bus Station once daily. Tickets cost $65–110 and the journey takes 8h.

Operators