The average bus between Otay Mesa and San Diego takes 1h 34m and the fastest bus takes 1h 14m. There is an hourly bus service from Otay Mesa to San Diego. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Otay Mesa and San Diego. The earliest departure is at 5:03 AM in the morning, and the last departure from Otay Mesa is at 9:48 PM which arrives into San Diego at 5:39 AM. All services require a transfer, and take on average 1h 34m. The schedules shown below are for the next available departures.

1h 27m • 1 change

1h 31m • 1 change

1h 31m • 1 change

1h 31m • 1 change

1h 21m • 1 change

1h 35m • 1 change

1h 26m • 1 change

1h 34m • 1 change

1h 15m • 1 change

1h 16m • 1 change

1h 14m • 1 change

1h 20m • 1 change
Want to know about travelling from Otay Mesa to San Diego? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Otay Mesa to San Diego. However, there are services departing from Otay Mesa station and arriving at San Diego station via Otay Mesa Transit Center. The journey, including transfers, takes approximately 1h 34m.
Otay Mesa to San Diego bus services, operated by San Diego Metro Transit, depart from Otay Mesa Rd & Cactus Rd station.
Otay Mesa to San Diego bus services, operated by San Diego Metro Transit, arrive at Broadway & 4th Av station.
The distance between Otay Mesa and San Diego is 23.5 km. The road distance is 47 km.
You can take a bus from Otay Mesa Rd & Cactus Rd to Broadway & 4th Av via Otay Mesa Transit Center in around 1h 29m.