The average bus between Otay Mesa and San Diego–Tijuana takes 44 min and the fastest bus takes 32 min. There is an hourly bus service from Otay Mesa to San Diego–Tijuana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Otay Mesa and San Diego–Tijuana. The earliest departure is at 5:01 AM in the morning, and the last departure from Otay Mesa is at 8:43 PM which arrives into San Diego–Tijuana at 9:39 PM. All services require a transfer, and take on average 44 min. The schedules shown below are for the next available departures.

44 min • 1 change

44 min • 1 change

48 min • 1 change

59 min • 1 change

37 min • 1 change

32 min • 1 change

58 min • 1 change

38 min • 1 change

37 min • 1 change

32 min • 1 change

58 min • 1 change

38 min • 1 change
Want to know about travelling from Otay Mesa to San Diego–Tijuana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Otay Mesa to San Diego–Tijuana. However, there are services departing from Otay Mesa station and arriving at San Diego–Tijuana station via Iris Avenue Transit Center. The journey, including transfers, takes approximately 44 min.
Otay Mesa to San Diego–Tijuana bus services, operated by San Diego Metro Transit, depart from Otay Mesa Rd & Cactus Rd station.
Otay Mesa to San Diego–Tijuana bus services, operated by San Diego Metro Transit, arrive at San Ysidro Transit Center station.
The distance between Otay Mesa and San Diego–Tijuana is 4.5 km. The road distance is 13 km.
You can take a bus from Otay Mesa Rd & Cactus Rd to San Ysidro Transit Center via Iris Avenue Transit Center in around 45 min.