Otay Mesa to Santa Ana Buses

Otay Mesa to Santa Ana buses

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Trip Overview

The average bus between Otay Mesa and Santa Ana takes 4h 35m and the fastest bus takes 2h 30m. The bus service runs several times per day from Otay Mesa to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 35m
Duration: 111 mi
Distance: $32
Average price: Every 4 hours
Frequency

Bus

best

Take the bus from San Ysidro to Santa Anabus Lxus 3126 / ...

3h 15m

$22–38

Otay Mesa to Santa Ana bus times

Buses run every 4 hours between Otay Mesa and Santa Ana. The earliest departure is at 5:01 AM in the morning, and the last departure from Otay Mesa is at 8:43 PM which arrives into Santa Ana at 7:35 AM. All services require a transfer at Iris Avenue Transit Center and take an average of 4h 35m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

3:43 PM → 10:00 PM
3h 17m • 2 changes
5:43 PM → 9:20 PM
3h 37m • 2 changes
6:43 PM → 1:00 AM
Arrives next day
3h 17m • 2 changes
8:43 PM → 7:35 AM
Arrives next day
10h 52m • 2 changes

Departing Monday, November 9, 2026

5:01 AM → 12:00 PM
3h 59m • 2 changes
8:48 AM → 3:45 PM
3h 57m • 2 changes
10:45 AM → 5:45 PM
4h • 2 changes
4:30 PM → 10:00 PM
2h 30m • 2 changes
Show more

Departing Tuesday, November 10, 2026

5:01 AM → 12:00 PM
3h 59m • 2 changes
8:48 AM → 3:45 PM
3h 57m • 2 changes
10:45 AM → 5:45 PM
4h • 2 changes
4:30 PM → 10:00 PM
2h 30m • 2 changes
Show more

Departing Wednesday, November 11, 2026

5:01 AM → 12:00 PM
3h 59m • 2 changes
8:48 AM → 3:45 PM
3h 57m • 2 changes
10:45 AM → 5:45 PM
4h • 2 changes
4:30 PM → 10:00 PM
2h 30m • 2 changes
Show more

Departing Thursday, November 12, 2026

5:01 AM → 12:00 PM
3h 59m • 2 changes
8:48 AM → 3:45 PM
3h 57m • 2 changes
10:45 AM → 5:45 PM
4h • 2 changes
4:30 PM → 10:00 PM
2h 30m • 2 changes
Show more

Departing Friday, November 13, 2026

5:01 AM → 12:00 PM
3h 59m • 2 changes
8:48 AM → 3:45 PM
3h 57m • 2 changes
10:45 AM → 5:45 PM
4h • 2 changes
4:30 PM → 10:00 PM
2h 30m • 2 changes
Show more

Departing Saturday, November 14, 2026

8:28 AM → 3:45 PM
4h 17m • 2 changes
10:28 AM → 5:45 PM
4h 17m • 2 changes
4:28 PM → 10:00 PM
2h 32m • 2 changes
6:28 PM → 1:00 AM
Arrives next day
3h 32m • 2 changes

Frequently asked questions

Want to know about travelling from Otay Mesa to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.