Bus Otay Mesa to Santa Ana from $29 | Tickets & Timetables

Otay Mesa to Santa Ana buses

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Trip Overview

The average bus between Otay Mesa and Santa Ana takes 3h 44m and the fastest bus takes 2h 30m. The bus service runs several times per day from Otay Mesa to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 44m
Duration: 111 mi
Distance: $29
Average price: Every 4 hours
Frequency

Bus

best

Take the bus from San Ysidro to Santa Anabus Lxus 3126 / ...

3h 15m

$20–45

Otay Mesa to Santa Ana bus times

Buses run every 4 hours between Otay Mesa and Santa Ana. The earliest departure is at 5:01 AM in the morning, and the last departure from Otay Mesa is at 8:43 PM which arrives into Santa Ana at 4:15 AM. All services require a transfer at Iris Avenue Transit Center and take an average of 3h 44m. The schedules shown below are for the next available departures.

Departing Friday, August 14, 2026

5:01 AM → 12:00 PM
6h 59m • 2 changes
8:48 AM → 3:45 PM
6h 57m • 2 changes
10:45 AM → 5:45 PM
7h • 2 changes
4:30 PM → 10:00 PM
5h 30m • 2 changes
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Departing Saturday, August 15, 2026

8:28 AM → 3:45 PM
7h 17m • 2 changes
10:28 AM → 5:45 PM
7h 17m • 2 changes
4:28 PM → 10:00 PM
5h 32m • 2 changes
5:28 PM → 9:20 PM
3h 52m • 2 changes
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Departing Sunday, August 16, 2026

8:43 AM → 3:45 PM
7h 2m • 2 changes
10:43 AM → 5:45 PM
7h 2m • 2 changes
3:43 PM → 10:00 PM
6h 17m • 2 changes
5:43 PM → 9:20 PM
3h 37m • 2 changes
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Departing Monday, August 17, 2026

5:01 AM → 12:00 PM
6h 59m • 2 changes
8:48 AM → 3:45 PM
6h 57m • 2 changes
10:45 AM → 5:45 PM
7h • 2 changes
4:30 PM → 10:00 PM
5h 30m • 2 changes
Show more

Departing Tuesday, August 18, 2026

5:01 AM → 12:00 PM
6h 59m • 2 changes
8:48 AM → 3:45 PM
6h 57m • 2 changes
10:45 AM → 5:45 PM
7h • 2 changes
4:30 PM → 10:00 PM
5h 30m • 2 changes
Show more

Departing Wednesday, August 19, 2026

5:01 AM → 12:00 PM
6h 59m • 2 changes
8:48 AM → 3:45 PM
6h 57m • 2 changes
10:45 AM → 5:45 PM
7h • 2 changes
4:30 PM → 10:00 PM
5h 30m • 2 changes
Show more

Departing Thursday, August 20, 2026

5:01 AM → 12:00 PM
6h 59m • 2 changes
8:48 AM → 3:45 PM
6h 57m • 2 changes
10:45 AM → 5:45 PM
7h • 2 changes
4:30 PM → 10:00 PM
5h 30m • 2 changes
Show more

Frequently asked questions

Want to know about travelling from Otay Mesa to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.