Otay Mesa to Santa Ana Buses

Otay Mesa to Santa Ana buses

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Trip Overview

The average bus between Otay Mesa and Santa Ana takes 4h 35m and the fastest bus takes 2h 30m. The bus service runs several times per day from Otay Mesa to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 35m
Duration: 111 mi
Distance: $32
Average price: Every 4 hours
Frequency

Bus

best

Take the bus from San Ysidro to Santa Anabus Lxus 3126 / ...

3h 15m

$22–37

Otay Mesa to Santa Ana bus times

Buses run every 4 hours between Otay Mesa and Santa Ana. The earliest departure is at 5:01 AM in the morning, and the last departure from Otay Mesa is at 8:43 PM which arrives into Santa Ana at 7:35 AM. All services require a transfer at Iris Avenue Transit Center and take an average of 4h 35m. The schedules shown below are for the next available departures.

Departing Wednesday, October 21, 2026

4:30 PM → 10:00 PM
2h 30m • 2 changes
6:01 PM → 9:20 PM
3h 19m • 2 changes
6:32 PM → 1:00 AM
Arrives next day
3h 28m • 2 changes
8:18 PM → 7:35 AM
Arrives next day
11h 17m • 2 changes

Departing Thursday, October 22, 2026

5:01 AM → 12:00 PM
3h 59m • 2 changes
8:48 AM → 3:45 PM
3h 57m • 2 changes
10:45 AM → 5:45 PM
4h • 2 changes
4:30 PM → 10:00 PM
2h 30m • 2 changes
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Departing Friday, October 23, 2026

5:01 AM → 12:00 PM
3h 59m • 2 changes
8:48 AM → 3:45 PM
3h 57m • 2 changes
10:45 AM → 5:45 PM
4h • 2 changes
4:30 PM → 10:00 PM
2h 30m • 2 changes
Show more

Departing Saturday, October 24, 2026

8:28 AM → 3:45 PM
4h 17m • 2 changes
10:28 AM → 5:45 PM
4h 17m • 2 changes
4:28 PM → 10:00 PM
2h 32m • 2 changes
5:28 PM → 9:20 PM
3h 52m • 2 changes
Show more

Departing Sunday, October 25, 2026

8:43 AM → 3:45 PM
4h 2m • 2 changes
10:43 AM → 5:45 PM
4h 2m • 2 changes
3:43 PM → 10:00 PM
3h 17m • 2 changes
5:43 PM → 9:20 PM
3h 37m • 2 changes
Show more

Departing Monday, October 26, 2026

5:01 AM → 12:00 PM
3h 59m • 2 changes
8:48 AM → 3:45 PM
3h 57m • 2 changes
10:45 AM → 5:45 PM
4h • 2 changes
4:30 PM → 10:00 PM
2h 30m • 2 changes
Show more

Departing Tuesday, October 27, 2026

5:01 AM → 12:00 PM
3h 59m • 2 changes
8:48 AM → 3:45 PM
3h 57m • 2 changes
10:45 AM → 5:45 PM
4h • 2 changes
4:30 PM → 10:00 PM
2h 30m • 2 changes
Show more

Frequently asked questions

Want to know about travelling from Otay Mesa to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.