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Otay Mesa to Santa Barbara buses

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Trip Overview

The average bus between Otay Mesa and Santa Barbara takes 14h 40m and the fastest bus takes 14h 27m. The bus runs, on average, 3 times per week from Otay Mesa to Santa Barbara. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

14h 40m
Duration
249 mi
Distance
$59
Average price
3 times a week
Frequency

Otay Mesa to Santa Barbara bus times

Buses run 3 times a week between Otay Mesa and Santa Barbara. The earliest departure is at 8:18 PM in the evening, and the last departure from Otay Mesa is at 8:43 PM which arrives into Santa Barbara at 11:10 AM. All services require a transfer at Iris Avenue Transit Center and take an average of 14h 40m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    San Diego Metro TransitSan Diego Metro TransitFlixbus USAFlixbus USA14h 42m • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    San Diego Metro TransitSan Diego Metro TransitFlixbus USAFlixbus USA14h 27m • 3 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    San Diego Metro TransitSan Diego Metro TransitFlixbus USAFlixbus USA14h 52m • 3 changes

Frequently asked questions

Want to know about travelling from Otay Mesa to Santa Barbara? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Otay Mesa to Santa Barbara.ExpandLaunch map view
  • Distance: 249 mi
  • Duration: 14h 40m

What companies run services between Otay Mesa, CA, USA and Santa Barbara, CA, USA?

You can take a bus from Otay Mesa Rd & Cactus Rd to Santa Barbara Bus Stop via Iris Avenue Transit Center, San Ysidro Bus Terminal, and Los Angeles Union Station in around 8h 5m.

Operators