The average bus between Otay Mesa and Santee takes 3h 17m and the fastest bus takes 2h 50m. There is a bus service every few hours from Otay Mesa to Santee. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Otay Mesa and Santee. The earliest departure is at 5:03 AM in the morning, and the last departure from Otay Mesa is at 9:48 PM which arrives into Santee at 6:56 AM. All services require a transfer at Otay Mesa Transit Center and take an average of 3h 17m. The schedules shown below are for the next available departures.



2h 51m • 3 changes



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3h 2m • 3 changes



3h 7m • 3 changes



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3h 6m • 3 changes



3h • 3 changes
Want to know about travelling from Otay Mesa to Santee? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Otay Mesa to Santee. However, there are services departing from Otay Mesa station and arriving at Santee station via Broadway & Park Bl. The journey, including transfers, takes approximately 3h 17m.
Otay Mesa to Santee bus services, operated by San Diego Metro Transit, depart from Otay Mesa Transit Center station.
Otay Mesa to Santee bus services, operated by San Diego Metro Transit, arrive at Grossmont College station.
The distance between Otay Mesa and Santee is 30.7 km. The road distance is 73 km.
You can take a bus from Otay Mesa Rd & Cactus Rd to Grossmont College via Otay Mesa Transit Center, Broadway & Park Bl, 11th Av & Broadway, SDSU Transit Center, and College Av & SDSU Transit Center in around 3h 24m.