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Otay Mesa to Tucson buses

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Trip Overview

The average bus between Otay Mesa and Tucson takes 25h 34m and the fastest bus takes 24h 41m. The bus runs, on average, 6 times per week from Otay Mesa to Tucson. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

25h 34m
Duration
518 mi
Distance
$112
Average price
6 times a week
Frequency

Otay Mesa to Tucson bus times

Buses run 6 times a week between Otay Mesa and Tucson. The earliest departure is at 7:43 AM in the morning, and the last departure from Otay Mesa is at 8:18 AM which arrives into Tucson at 2:31 PM. All services require a transfer at Iris Avenue Transit Center and take an average of 25h 34m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

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    Arrives next day

    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USAFlixbus USASun Tran25h 18m • 5 changes

Departing Monday, November 9, 2026

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    Arrives next day

    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USAFlixbus USASun Tran29h 13m • 5 changes

Departing Tuesday, November 10, 2026

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    Arrives next day

    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USAFlixbus USASun Tran24h 43m • 5 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USAFlixbus USASun Tran24h 43m • 5 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USAFlixbus USASun Tran24h 43m • 5 changes

Departing Friday, November 13, 2026

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    Arrives next day

    San Diego Metro TransitSan Diego Metro TransitGreyhound USAFlixbus USAFlixbus USASun Tran24h 41m • 5 changes

Frequently asked questions

Want to know about travelling from Otay Mesa to Tucson? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Otay Mesa to Tucson.ExpandLaunch map view
  • Distance: 518.4 mi
  • Duration: 25h 34m

What companies run services between Otay Mesa, CA, USA and Tucson, AZ, USA?

You can take a bus from Otay Mesa Rd & Cactus Rd to Broadway/Country Club via Iris Avenue Transit Center, San Ysidro Bus Terminal, Yuma County Area Transit, Phoenix Sky Harbor Airport/44th Street Sky Train Station, Tucson Downtown, and Downtown Ronstadt Center in around 14h 17m.

Operators