The average bus between Otranto and Brindisi takes 2h 37m and the fastest bus takes 2h 9m. The bus service runs several times per day from Otranto to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a day between Otranto and Brindisi. The earliest departure is at 7:10 AM in the morning, and the last departure from Otranto is at 6:48 PM which arrives into Brindisi at 9:29 PM. All services require a transfer at Lecce - Camera di Commercio/Stazione and take an average of 2h 37m. The schedules shown below are for the next available departures.

2h 44m • 1 change

2h 55m • 1 change

2h 9m • 1 change

36 min • 1 change

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2h 55m • 1 change

2h 9m • 1 change

36 min • 1 change

2h 44m • 1 change

2h 55m • 1 change

2h 9m • 1 change

36 min • 1 change

2h 44m • 1 change

2h 55m • 1 change

2h 9m • 1 change

36 min • 1 change

2h 44m • 1 change

2h 55m • 1 change

2h 9m • 1 change

36 min • 1 change

2h 44m • 1 change

2h 55m • 1 change

2h 9m • 1 change

36 min • 1 change
Want to know about travelling from Otranto to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Otranto to Brindisi. However, there are services departing from Otranto station and arriving at Brindisi station via Lecce - Camera di Commercio/Stazione. The journey, including transfers, takes approximately 2h 37m.
Otranto to Brindisi bus services, operated by Salento in bus, depart from Otranto - Stazione FSE station.
Otranto to Brindisi bus services, operated by Salento in bus, arrive at Lecce - Camera di Commercio/Stazione station.
Book your Otranto to Brindisi bus tickets online with Salento in bus and FlixBus.
The distance between Otranto and Brindisi is 71.2 km. The road distance is 89 km.
Salento in bus operates a bus from Otranto - Stazione FSE to Lecce - Camera di Commercio/Stazione every 2 hours. Tickets cost €2–4 and the journey takes 1h 32m.