The average bus between Paddington and Manchester takes 4h 42m and the fastest bus takes 4h 12m. There is a bus service every few hours from Paddington to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Paddington and Manchester. The earliest departure is at 7:01 AM in the morning, and the last departure from Paddington is at 9:10 PM which arrives into Manchester at 2:00 AM. All services require a transfer at Finchley Road / O2 Centre and take an average of 4h 42m. The schedules shown below are for the next available departures.

4h 54m • 1 change
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4h 23m • 1 changeArrives next day

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5h 12m • 1 change
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5h 12m • 1 changeWant to know about travelling from Paddington to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Paddington to Manchester. However, there are services departing from London, Finchley Road ("Subway" restaurant) station and arriving at Manchester, Shudehill Interchange station via Manchester, Shudehill Interchange station. The journey, including transfers, takes approximately 4h 42m.
Paddington to Manchester bus services, operated by FlixBus, depart from London, Finchley Road ("Subway" restaurant) station.
Paddington to Manchester bus services, operated by FlixBus, arrive at Manchester, Shudehill Interchange station.
The distance between Paddington and Manchester is 259.1 km. The road distance is 294 km.
FlixBus operates a bus from London, Finchley Road ("Subway" restaurant) to Manchester, Shudehill Interchange every 3 hours. Tickets cost £23–35 and the journey takes 4h 10m.