The average bus between Paddington and Manchester takes 4h 42m and the fastest bus takes 4h 12m. There is a bus service every few hours from Paddington to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Paddington and Manchester. The earliest departure is at 7:01 AM in the morning, and the last departure from Paddington is at 9:10 PM which arrives into Manchester at 2:00 AM. All services require a transfer at Finchley Road / O2 Centre and take an average of 4h 42m. The schedules shown below are for the next available departures.

4h 38m • 1 change

5h 12m • 1 change

4h 52m • 1 change

4h 32m • 1 change

4h 32m • 1 change

5h 17m • 1 change

4h 59m • 1 change

4h 39m • 1 change

4h 39m • 1 change

5h 15m • 1 change

5h 4m • 1 change

4h 34m • 1 change

4h 38m • 1 change

5h 12m • 1 change

4h 52m • 1 change

4h 32m • 1 change
Want to know about travelling from Paddington to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Paddington to Manchester. However, there are services departing from Paddington station and arriving at Manchester station via Manchester, Shudehill Interchange. The journey, including transfers, takes approximately 4h 42m.
Paddington to Manchester bus services, operated by Metroline Travel, depart from London, Finchley Road ("Subway" restaurant) station.
Paddington to Manchester bus services, operated by Metroline Travel, arrive at Manchester, Shudehill Interchange station.
Book your Paddington to Manchester bus tickets online with Metroline Travel and FlixBus.
The distance between Paddington and Manchester is 259.1 km. The road distance is 313 km.
FlixBus operates a bus from London, Finchley Road ("Subway" restaurant) to Manchester, Shudehill Interchange hourly. Tickets cost £20–35 and the journey takes 4h 10m.