The average bus between Palermo and La Spezia takes 23h 3m and the fastest bus takes 22h. There is at least one bus per day from Palermo to La Spezia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Palermo and La Spezia. The earliest departure is at 3:25 PM in the afternoon, and the last departure from Palermo is at 9:10 PM which arrives into La Spezia at 7:10 PM. All services require a transfer, and take on average 23h 3m. The schedules shown below are for the next available departures.
Arrives next day

23h 45m • 1 change
Arrives next day

22h • 1 change
Arrives next day

23h 45m • 1 change
Arrives next day

22h • 1 change
Want to know about travelling from Palermo to La Spezia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Palermo to La Spezia. However, there are services departing from Palermo station and arriving at La Spezia station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 23h 3m.
Palermo to La Spezia bus services, operated by FlixBus, depart from Palermo station.
Palermo to La Spezia bus services, operated by FlixBus, arrive at La Spezia station.
Book your Palermo to La Spezia bus tickets online with FlixBus and BlaBlaCar Bus.
The distance between Palermo and La Spezia is 726 km. The road distance is 1,413 km.
You can take a bus from Palermo to La Spezia via Florence Villa Constanza Bus Station in around 20h 10m.