The average bus between Palermo and Otranto takes 18h 10m and the fastest bus takes 15h 5m. The bus service runs several times per day from Palermo to Otranto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Palermo and Otranto. The earliest departure is at 3:25 PM in the afternoon, and the last departure from Palermo is at 9:10 PM which arrives into Otranto at 7:45 PM. All services require a transfer at Catania Central Bus Station and take an average of 18h 10m. The schedules shown below are for the next available departures.
Arrives next day

15h 5m • 1 changeArrives next day

22h 35m • 1 changeArrives next day

15h 5m • 1 changeArrives next day

26h 35m • 1 changeWant to know about travelling from Palermo to Otranto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Palermo to Otranto. However, there are services departing from Palermo station and arriving at Otranto station via Catania Central Bus Station station. The journey, including transfers, takes approximately 18h 10m.
Palermo to Otranto bus services, operated by FlixBus, depart from Palermo Via Tommaso Fazello station.
Palermo to Otranto bus services, operated by FlixBus, arrive at Otranto, Via Orte station.
The distance between Palermo and Otranto is 497.4 km. The road distance is 877 km.
You can take a bus from Palermo Via Tommaso Fazello to Otranto, Via Orte via Catania Central Bus Station and Catania, Via D'Amico in around 13h 25m.