The average bus between Palm Desert and Santa Cruz takes 16h 35m and the fastest bus takes 12h 13m. The bus service runs several times per day from Palm Desert to Santa Cruz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Palm Desert and Santa Cruz. The earliest departure is at 1:52 PM in the afternoon, and the last departure from Palm Desert is at 10:27 PM which arrives into Santa Cruz at 9:28 PM. All services require a transfer at Hwy 111 & Golf Center Pkwy and take an average of 16h 35m. The schedules shown below are for the next available departures.
Arrives next day



14h 3m • 3 changes
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19h 53m • 3 changes
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12h 13m • 3 changes
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19h 49m • 3 changes
Arrives next day



12h 13m • 3 changes
Arrives next day



19h 49m • 3 changes
Want to know about travelling from Palm Desert to Santa Cruz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Palm Desert to Santa Cruz. However, there are services departing from Palm Desert station and arriving at Santa Cruz station via Los Angeles Union Station station. The journey, including transfers, takes approximately 16h 35m.
Palm Desert to Santa Cruz bus services, operated by Sunline Transit, depart from Indio Bus Station.
Palm Desert to Santa Cruz bus services, operated by Sunline Transit, arrive at Soquel Ave & Front station.
The distance between Palm Desert and Santa Cruz is 627.2 km. The road distance is 828 km.
You can take a bus from Hwy 111 at San Luis Rey to Soquel Ave & Front via Hwy 111 & Golf Center Pkwy, Indio Bus Station, Los Angeles Union Station, San Jose Diridon Station, and Diridon Station in around 12h 59m.