- Distance: 255.7 km
- Duration: 4h 30m
The bus between Panama City and Santiago takes 4h 30m. The bus service runs several times per day from Panama City to Santiago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Panama City and Santiago. The earliest departure is at 7:30 AM in the morning, and the last departure from Panama City is at 8:00 PM which arrives into Santiago at 12:30 AM. All services run direct with no transfers required, and take on average 4h 30m. The schedules shown below are for the next available departures.
Arrives next day
Arrives next day
Arrives next day
Arrives next day
Want to know about travelling from Panama City to Santiago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
Yes, there is a direct bus departing from Panama City station and arriving at Santiago station. Services depart 4 times a day, and operate 4 times a day. The journey takes approximately 4h 30m.
Panama City to Santiago bus services, operated by Tranceibosa Bocas del Toro, depart from Panama City station.
Panama City to Santiago bus services, operated by Tranceibosa Bocas del Toro, arrive at Santiago station.
The distance between Panama City and Santiago is 189.1 km. The road distance is 256 km.
Panama Local Buses operates a bus from Panama City to Santiago hourly. Tickets cost $18 and the journey takes 3h 42m. Three other operators also service this route.
