The average bus between Penn Station NY and Hyannis takes 6h 40m and the fastest bus takes 6h 25m. The bus service runs several times per day from Penn Station NY to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Penn Station NY and Hyannis. The earliest departure is at 3:00 AM at night, and the last departure from Penn Station NY is at 2:30 PM which arrives into Hyannis at 9:35 PM. All services require a transfer at New York Midtown and take an average of 6h 40m. The schedules shown below are for the next available departures.

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Want to know about travelling from Penn Station NY to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Penn Station NY to Hyannis. However, there are services departing from Penn Station NY station and arriving at Hyannis station via Boston. The journey, including transfers, takes approximately 6h 40m.
Penn Station NY to Hyannis bus services, operated by Flixbus USA, depart from New York Midtown station.
Penn Station NY to Hyannis bus services, operated by Flixbus USA, arrive at Hyannis Transportation Center station.
The distance between Penn Station NY and Hyannis is 326.4 km. The road distance is 460 km.
You can take a vehicle from Penn Station NY to Hyannis Transportation Center via New York Midtown, Boston, and South Station Transp. Ctr in around 6h 44m.