The average bus between Penn Station and Hyannis takes 11h 42m and the fastest bus takes 10h 45m. The bus runs, on average, 6 times per week from Penn Station to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 6 times a week between Penn Station and Hyannis. The earliest departure is at 12:14 AM at night, and the last departure from Penn Station is at 9:59 PM which arrives into Hyannis at 9:35 AM. All services require a transfer at MCCULLOH ST & PRESTON ST nb and take an average of 11h 42m. The schedules shown below are for the next available departures.



12h 20m • 3 changes



12h 30m • 3 changes



11h 50m • 3 changes



10h 45m • 3 changes
Want to know about travelling from Penn Station to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Penn Station to Hyannis. However, there are services departing from Penn Station station and arriving at Hyannis station via New York Midtown. The journey, including transfers, takes approximately 11h 42m.
Penn Station to Hyannis bus services, operated by Maryland Transit, depart from Baltimore Downtown Bus Station.
Penn Station to Hyannis bus services, operated by Maryland Transit, arrive at Hyannis Transportation Center station.
The distance between Penn Station and Hyannis is 595.6 km. The road distance is 846 km.
You can take a vehicle from Penn Station to Hyannis Transportation Center via MCCULLOH ST & PRESTON ST nb, HAINES ST & WARNER ST wb, Baltimore Downtown Bus Station, New York Midtown, Boston, and Boston South Station in around 12h 49m.