The average bus between Penn Station and Hyannis takes 12h 2m and the fastest bus takes 11h 32m. The bus service runs several times per day from Penn Station to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Penn Station and Hyannis. The earliest departure is at 12:14 AM at night, and the last departure from Penn Station is at 9:59 PM which arrives into Hyannis at 10:15 AM. All services require a transfer at MCCULLOH ST & PRESTON ST nb and take an average of 12h 2m. The schedules shown below are for the next available departures.


11h 35m • 2 changesArrives next day


12h 11m • 2 changesArrives next day


12h 32m • 2 changes

11h 32m • 2 changesArrives next day


11h 45m • 2 changesArrives next day


12h 15m • 2 changes

12h • 2 changesArrives next day


11h 45m • 2 changesArrives next day


12h 15m • 2 changes

12h • 2 changesArrives next day


11h 45m • 2 changesArrives next day


12h 15m • 2 changesWant to know about travelling from Penn Station to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Penn Station to Hyannis. However, there are services departing from Penn Station station and arriving at Hyannis station via Boston. The journey, including transfers, takes approximately 12h 2m.
Penn Station to Hyannis bus services, operated by Maryland Transit, depart from Baltimore Downtown Bus Station.
Penn Station to Hyannis bus services, operated by Maryland Transit, arrive at Hyannis Transportation Center station.
The distance between Penn Station and Hyannis is 595.6 km. The road distance is 854 km.
You can take a vehicle from Penn Station to Hyannis Transportation Center via MCCULLOH ST & PRESTON ST nb, HAINES ST & WARNER ST wb, Baltimore Downtown Bus Station, Boston, and Boston South Buses in around 12h 49m.