The average bus between Penzance and High Wycombe takes 10h 25m and the fastest bus takes 9h 39m. The bus service runs several times per day from Penzance to High Wycombe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Penzance and High Wycombe. The earliest departure is at 4:45 AM at night, and the last departure from Penzance is at 9:25 PM which arrives into High Wycombe at 7:04 AM. All services require a transfer, and take on average 10h 25m. The schedules shown below are for the next available departures.

11h 4m • 1 change

10h 9m • 1 change
Arrives next day

9h 39m • 1 change

10h 59m • 1 change

10h 4m • 1 change
Arrives next day

9h 39m • 1 change

11h 22m • 1 change

10h 16m • 1 change
Arrives next day

9h 39m • 1 change

11h 22m • 1 change

10h 16m • 1 change
Arrives next day

9h 39m • 1 change
Want to know about travelling from Penzance to High Wycombe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Penzance to High Wycombe. However, there are services departing from Penzance station and arriving at High Wycombe station via Heathrow Central Bus Station station. The journey, including transfers, takes approximately 10h 25m.
Penzance to High Wycombe bus services, operated by National Express, depart from Bus Station.
Penzance to High Wycombe bus services, operated by National Express, arrive at Heathrow Central Bus Station.
Book your Penzance to High Wycombe bus tickets online with National Express and Carousel Buses.
The distance between Penzance and High Wycombe is 375.5 km. The road distance is 504 km.
National Express operates a bus from Bus Station to Heathrow Central Bus Station every 4 hours. Tickets cost £55–140 and the journey takes 8h 5m.