The average bus between Penzance and Slough takes 9h 39m and the fastest bus takes 9h 1m. The bus service runs several times per day from Penzance to Slough. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Penzance and Slough. The earliest departure is at 4:45 AM at night, and the last departure from Penzance is at 9:25 PM which arrives into Slough at 6:26 AM. All services require a transfer, and take on average 9h 39m. The schedules shown below are for the next available departures.

10h 23m • 1 change

9h 23m • 1 change
Arrives next day

9h 3m • 1 change

10h 23m • 1 change

9h 23m • 1 change
Arrives next day

9h 3m • 1 change

10h 23m • 1 change

9h 23m • 1 change
Arrives next day

9h 3m • 1 change

10h 23m • 1 change

9h 23m • 1 change
Arrives next day

9h 3m • 1 change
Want to know about travelling from Penzance to Slough? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Penzance to Slough. However, there are services departing from Penzance station and arriving at Slough station via Heathrow Central Bus Station station. The journey, including transfers, takes approximately 9h 39m.
Penzance to Slough bus services, operated by National Express, depart from Bus Station.
Penzance to Slough bus services, operated by National Express, arrive at Heathrow Central Bus Station.
Book your Penzance to Slough bus tickets online with National Express and First Berkshire & The Thames Valley.
The distance between Penzance and Slough is 380 km. The road distance is 480 km.
National Express operates a bus from Bus Station to Heathrow Central Bus Station every 4 hours. Tickets cost £55–130 and the journey takes 8h 5m.