The average bus between Penzance and Southampton takes 12h 18m and the fastest bus takes 11h 15m. The bus service runs several times per day from Penzance to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Penzance and Southampton. The earliest departure is at 4:45 AM at night, and the last departure from Penzance is at 9:25 PM which arrives into Southampton at 9:30 AM. All services require a transfer, and take on average 12h 18m. The schedules shown below are for the next available departures.

13h 5m • 1 change

11h 45m • 1 change
Arrives next day

12h 5m • 1 change

13h 5m • 1 change

11h 45m • 1 change
Arrives next day

12h 5m • 1 change

13h 5m • 1 change

11h 45m • 1 change
Arrives next day

12h 5m • 1 change

13h 40m • 1 change

11h 15m • 1 change
Arrives next day

12h 25m • 1 change

13h • 1 change

11h 25m • 1 change
Arrives next day

12h 25m • 1 change
Want to know about travelling from Penzance to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Penzance to Southampton. However, there are services departing from Penzance station and arriving at Southampton station via Heathrow Central Bus Station station. The journey, including transfers, takes approximately 12h 18m.
Penzance to Southampton bus services, operated by National Express, depart from Bus Station.
Penzance to Southampton bus services, operated by National Express, arrive at Coach Station.
Book your Penzance to Southampton bus tickets online with National Express.
The distance between Penzance and Southampton is 305 km. The road distance is 576 km.
You can take a bus from Bus Station to Coach Station via Heathrow Central Bus Station in around 10h 22m.