The average bus between Pernes-les-Fontaines and Lyon takes 6h 43m and the fastest bus takes 4h 46m. The bus service runs several times per day from Pernes-les-Fontaines to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Pernes-les-Fontaines and Lyon. The earliest departure is at 7:16 AM in the morning, and the last departure from Pernes-les-Fontaines is at 8:39 PM which arrives into Lyon at 11:50 AM. All services require a transfer at PEM Gare Routière and take an average of 6h 43m. The schedules shown below are for the next available departures.



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Arrives next day



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5h 54m • 3 changes
Want to know about travelling from Pernes-les-Fontaines to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pernes-les-Fontaines to Lyon. However, there are services departing from Pernes-les-Fontaines station and arriving at Lyon station via Lyon. The journey, including transfers, takes approximately 6h 43m.
Pernes-les-Fontaines to Lyon bus services, operated by ZOU! Proximité, depart from Avignon station.
Pernes-les-Fontaines to Lyon bus services, operated by ZOU! Proximité, arrive at Lyon station.
The distance between Pernes-les-Fontaines and Lyon is 195.3 km. The road distance is 248 km.
FlixBus operates a bus from Avignon to Lyon every 4 hours. Tickets cost €19–35 and the journey takes 2h 40m. BlaBlaCar Bus also services this route every 4 hours.