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Philadelphia to Middlesex buses

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Trip Overview

The average bus between Philadelphia and Middlesex takes 4h 57m and the fastest bus takes 3h 32m. The bus service runs several times per day from Philadelphia to Middlesex. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 57m
Duration
121 mi
Distance
$25
Average price
3 times a day
Frequency

Philadelphia to Middlesex bus times

Buses run 3 times a day between Philadelphia and Middlesex. The earliest departure is at 9:00 AM in the morning, and the last departure from Philadelphia is at 11:55 PM which arrives into Middlesex at 5:32 AM. All services require a transfer at Harrisburg Bus Station and take an average of 4h 57m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Greyhound USARabbit Transit3h 34m • 1 change
  •  → 

    Arrives next day

    Greyhound USARabbit Transit11h 57m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Greyhound USARabbit Transit3h 32m • 1 change
  •  → 

    Greyhound USARabbit Transit3h 34m • 1 change
  •  → 

    Flixbus USARabbit Transit4h 22m • 1 change
  •  → 

    Arrives next day

    Greyhound USARabbit Transit11h 57m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Greyhound USARabbit Transit3h 32m • 1 change
  •  → 

    Greyhound USARabbit Transit3h 34m • 1 change
  •  → 

    Flixbus USARabbit Transit4h 22m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Flixbus USARabbit Transit5h 37m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Greyhound USARabbit Transit3h 32m • 1 change
  •  → 

    Greyhound USARabbit Transit3h 34m • 1 change
  •  → 

    Flixbus USARabbit Transit4h 22m • 1 change
  •  → 

    Arrives next day

    Flixbus USARabbit Transit5h 37m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Greyhound USARabbit Transit3h 32m • 1 change
  •  → 

    Greyhound USARabbit Transit3h 34m • 1 change

Frequently asked questions

Want to know about travelling from Philadelphia to Middlesex? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Philadelphia to Middlesex.ExpandLaunch map view
  • Distance: 121.3 mi
  • Duration: 4h 57m

What companies run services between Philadelphia, PA, USA and Middlesex, PA, USA?

You can take a bus from Philadelphia Bus Station to Carlisle Pike & Country Club Rd WB via Harrisburg Bus Station and Market Square Transfer Center in around 3h 38m.

Operators