The average bus between Philadelphia and Saint Charles takes 24h 49m and the fastest bus takes 22h 24m. The bus service runs several times per day from Philadelphia to Saint Charles. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Philadelphia and Saint Charles. The earliest departure is at 3:20 AM at night, and the last departure from Philadelphia is at 5:35 PM which arrives into Saint Charles at 4:59 PM. All services require a transfer at St Louis Bus Station and take an average of 24h 49m. The schedules shown below are for the next available departures.
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21h 54m • 2 changes
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23h 40m • 2 changes
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26h 32m • 2 changes
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21h 24m • 2 changes
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23h 24m • 2 changes
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26h 32m • 2 changes
Arrives next day


21h 24m • 2 changes
Arrives next day


23h 24m • 2 changes
Arrives next day


26h 32m • 2 changes
Arrives next day


21h 24m • 2 changes
Arrives next day


23h 24m • 2 changes
Want to know about travelling from Philadelphia to Saint Charles? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Philadelphia to Saint Charles. However, there are services departing from Philadelphia station and arriving at Saint Charles station via St Louis Bus Station station. The journey, including transfers, takes approximately 24h 49m.
Philadelphia to Saint Charles bus services, operated by Greyhound USA, depart from Philadelphia Bus Station.
Philadelphia to Saint Charles bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
The distance between Philadelphia and Saint Charles is 1,321.5 km. The road distance is 1,494 km.
Greyhound USA operates a bus from Philadelphia Bus Station to St Louis Bus Station 3 times a day. Tickets cost $140–270 and the journey takes 20h 50m.