The average bus between Piccadilly and Manchester takes 5h 37m and the fastest bus takes 4h 32m. There is a bus service every few hours from Piccadilly to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Piccadilly and Manchester. The earliest departure is at 1:41 AM at night, and the last departure from Piccadilly is at 11:16 PM which arrives into Manchester at 6:05 AM. All services require a transfer at Green Park station and take an average of 5h 37m. The schedules shown below are for the next available departures.

6h 3m • 1 change

5h 17m • 1 change

6h 2m • 1 change

5h 26m • 1 change

5h 53m • 1 change

4h 55m • 1 change

5h 9m • 1 change

4h 59m • 1 change

5h 53m • 1 change

4h 55m • 1 change

5h 9m • 1 change

4h 59m • 1 change
Want to know about travelling from Piccadilly to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Piccadilly to Manchester. However, there are services departing from Piccadilly station and arriving at Manchester station via Manchester, Shudehill Interchange. The journey, including transfers, takes approximately 5h 37m.
Piccadilly to Manchester bus services, operated by Arriva UK, depart from London, Finchley Road ("Subway" restaurant) station.
Piccadilly to Manchester bus services, operated by Arriva UK, arrive at Manchester, Shudehill Interchange station.
The distance between Piccadilly and Manchester is 261.3 km. The road distance is 316 km.
FlixBus operates a bus from London, Finchley Road ("Subway" restaurant) to Manchester, Shudehill Interchange hourly. Tickets cost £22–40 and the journey takes 4h 10m.